Fifth Mexican boy now aged 10 to 14 years. They suffered damage and injuries in the urinary tract due to an accident.
But the success of this cell engineering berbasil study recently published Monday, March 7, 2011 in the journal Lancet. This development was recorded as the first for the field of regenerative medicine.
Scientists have managed to make the urethra or bladder that carries urine out of the body. This artificial urethra using cells belong to these boys who first developed in the laboratory before implanted into the body of the boys.
The cells are allowed to grow and tissue engineered into the urethra. The researchers created two types of cells, namely to the outer layer of muscle cells and endothelial cell tube of cells to line blood vessels and other tubular structures such as inner lining.
Then the cells were implanted (implant) into the boy’s body from which the cell sheet began to form a new network. After four weeks, the team used a catheter to remove the children because they were finally able to urinate through the new urethra.
Biopsy showed the urethra results in this engineered layer of normal epithelial and smooth muscle in three months.
“Testing urine flow and tube diameter size showed that the urethral tissue engineering is still able to work after six years,” explained Dr. Anthony Atala, director of the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center in North Carolina, as reported by FoxNews.
Earlier, Dr teams. Atala never grow hollow organ that is used as a substitute for the bladder, which invested in 9 children in 1998. This offers a challenge because the urethra is a tubular structure (small tube-shaped).
According to him, the two cases between 1998 and now use a technique similar or almost the same.
“Basically, the patient came to us with people who are sick or injured. We take a very small part of the network, about half the size of a stamp,” explained Dr. Atala.
For the latest case, the team added growth factors that maintain cells and encouraged to breed in large numbers.
Dr Tim. Atala continue to monitor these children over the last six years and ensure that the urethra is working properly.
“This cell-based therapy complementary medicines and devices in order to cure the unmet needs of the media in our generation, such as blindness, diabetes, heart failure, Parkinson’s disease and stokes,” explained Dr. Atala.
Meanwhile, Chris Mason, regenerative medicine expert at University College London who was not involved in the study stated that the urethra is completely successful grown in the laboratory by using living tubes (tube life) that drains urine from the bladder.
“This shows the strength of cell therapy,” said Mason.
According to him, when an organ or tissue damage or trauma and can not be repaired anymore, then no drugs or mechanical devices to restore and make the patient back to normal.
“This cell-based therapy offers a potential cure later on,” continued Mason.
Urethral defects can be caused by injury, illness or disability since birth. Temporary disability due to urinary tract tube is shorter or larger can still be repaired with tissue graft, usually taken from the skin or lining the cheeks.
But if the graft fails, then half of these cases often lead to infection, bleeding and difficulty urinating.
Powered by Facebook Comments