Cambridge, thick and wrinkled skin that characterizes Shar-Pei dogs have close links with seasonal fever in humans. The cause is the same, namely the specific gene abnormalities in humans could lead to an increased risk of inflammation.
The study, published in the latest edition of the journal PLoS Genetics, reveals, wrinkled skin on Shar-Pei dog triggered by compounds Hyaluronan. Excessive levels of dog breeds from China because it has a mutation in the gene Hyaluronan synthase 2 (HAS2).
The researchers also revealed that elevated levels of compounds Hyaluronan experienced by humans although it is not causing the skin becomes wrinkled. In humans, these compounds increase occurs when the body against attacks from germs that cause infectious diseases.
When Hyaluronan levels increase, activate the body’s immune system and trigger inflammation (autoinflammatory). In addition to typical symptoms of spots marked by redness (rubor), swelling (tumor) and pain (dolor), inflammation is also characterized by fever (calor).
These findings reveal the cause of seasonal fever syndrome (periodic fever syndrome, inflammatory auto) experienced by some people as a hereditary disease.So far, the majority of reported cases is not known what the real cause.
Almost like a fever in general, symptoms caused by seasonal fever syndrome, among others, are as follows.
Pain in joints
Seasonal fever is just one of many symptoms that accompany the syndrome autoinflamatory or inflammation due to a genetic disorder in humans. Other symptoms are also commonly reported lesions (sores) in the skin of unknown cause.
“The finding that seasonal fever Hyaluronan is the trigger to open the way for other research in the field autoinflamatory or inflammation due to genetic abnormalities in humans,” said Kerstin Lindblad-Toh of the Broad Institute in Cambridge, as quoted from HealthDay.
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